Matrix Metalloproteinase Responsive, Proximity-Activated Polymeric Nanoparticles for siRNA Delivery
نویسندگان
چکیده
منابع مشابه
MMP-Responsive, Proximity-activated Targeting Polymeric Nanoparticles for siRNA Delivery
SUMMARY A smart polymeric nanoparticle (SPN) with matrix metalloproteinase-7 (MMP-7) dependent proximityactivated targeting (PAT) has been designed and tested for targeted intracellular siRNA delivery to MMP-7 overexpressing tissues (i.e., tumor metastases). With this novel PAT-SPN design, a removable PEG corona mitigates cytotoxicity and nonspecific uptake in normal tissues. Exposure to MMP (i...
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ژورنال
عنوان ژورنال: Advanced Functional Materials
سال: 2013
ISSN: 1616-301X
DOI: 10.1002/adfm.201202215